论文部分内容阅读
儿童细菌性脑膜炎经早期诊断和适当抗菌治疗,可使病死率明显下降。但长期存活者中有后遗症者仍占较高比率,甚至有些起初恢复好的儿童,最终仍可发现有精细感觉和语言方面的缺陷。神经系统后遗症的病理生理尚不清楚。皮层血管壁局灶性坏死和栓塞可引起明显的神经缺陷。脑水肿、交通性和非交通性脑积水、硬脑膜下大量积液、细菌毒素引起的脑病、电解质紊乱和抗菌素的神经毒性等,都可引起神经缺陷。
Children with bacterial meningitis by early diagnosis and appropriate antibacterial therapy, can significantly reduce the case fatality rate. However, those with long-term survivors still have a high rate of sequelae, and even some children who initially recovered may eventually find fine senses and language deficits. The pathophysiology of neurological sequelae remains unclear. Focal vessel wall necrosis and embolism can cause significant neurological deficits. Brain edema, traffic and non-traffic hydrocephalus, a large number of subdural effusion, bacterial toxin-induced encephalopathy, electrolyte disorders and antibiotic neurotoxicity, can cause neurological deficiencies.