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本文研究了铁缺乏大鼠与正常鼠对肺炎链球菌感染的敏感性。缺铁组用25只断乳雄性大鼠,喂以人工合成缺铁饲料;对照组26只,饲料中补充硫酸亚铁使含铁100 ppm。喂养三周后,缺乏组和对照组动物的血红蛋白含量平均值分别为5.4及13.8克。缺铁组动物体重仅及对照组的83%。用肺炎链球菌6302(Streptcoccus pneumoniae 6302,光滑2型)培养液配成10°、10~(-1)10~(-H)及10~(-5)浓度接种液。经预备试验,此最高浓度可使对照大鼠100%死亡,最稀浓度可使全部存活。将不同浓度菌液0.5毫升接种于大鼠腹腔内,观察四天。对照组大鼠对四种浓度接种液的抗感染力均较缺铁组强,动物死亡较少,存活时间较长。接种10~(-8)浓度菌液后对照组动物全部存活而缺铁组6只鼠在接种后第三天全部死亡;接种10~(-5)度菌液第四天对照组8只鼠中有6只存
This article studies the iron-deficient rats and normal mice susceptibility to S. pneumoniae infection. In the iron-deficient group, 25 weanling male rats were fed artificial iron-deficient feed. In the control group, 26 rats were fed ferrous sulfate supplemented with 100 ppm iron. After three weeks of feeding, the average hemoglobin content of the lacking and control animals was 5.4 and 13.8 grams, respectively. Iron deficiency animals only 83% of body weight and control group. Streptococcus pneumoniae 6302 (smooth type 2) medium was used to prepare 10 °, 10 -1 10 ~ (-H) and 10 ~ (-5) concentrations of inoculum. After preliminary testing, this maximum concentration of 100% of the control rats can die, the most dilute concentration can make all survive. 0.5 ml of different concentrations of bacteria were inoculated into the abdominal cavity of rats and observed for four days. The anti-infective power of the four groups of inoculated liquid of the control group rats was stronger than that of the iron-deficient group, with fewer animal deaths and longer survival time. All the animals in the control group survived after inoculation with 10 ~ (-8) concentration of bacteria, and all 6 rats died in the third day after inoculation with 10 ~ (-5) There are 6 save