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目的:探讨慢性心力衰竭患者血清心肌肌钙蛋白T水平与心脏功能及远期心脏事件的关系。方法:心力衰竭患者68例,按照纽约心脏协会(NYHA)心功能分级标准分为3组,测定心力衰竭患者血清心肌肌钙蛋白T水平,观察其与心脏功能及心力衰竭患者远期心脏事件的关系。并选取同期健康体检者作为对照组。结果:68例心力衰竭患者中31例血清心肌肌钙蛋白T升高,心功能Ⅲ级心肌肌钙蛋白T升高的检出率(66.7%)比心功能Ⅱ级检出率(8.6%)显著增高(P<0.05),心功能IV级心肌肌钙蛋白T升高的检出率(100%)比心功能Ⅲ级患者明显增高(P<0.05)。68例心力衰竭患者远期随访,随访时间(14±6)个月,心肌肌钙蛋白T正常组远期心脏事件16例次,升高组远期心脏事件33例次(P<0.01)。结论:心功能越差心肌肌钙蛋白T升高的检出率越大,血清心肌肌钙蛋白T不仅是心力衰竭患者心肌损伤的敏感标志物,而且是远期心脏事件的独立预测因子。
Objective: To investigate the relationship between serum cardiac troponin T level and cardiac function and long-term cardiac events in patients with chronic heart failure. Methods: Sixty-eight patients with heart failure were divided into three groups according to New York Heart Association (NYHA) classification of cardiac function. Serum cardiac troponin T level was measured in patients with heart failure. The cardiac function and heart failure in patients with heart failure relationship. And select the same period of health examination as a control group. Results: Serum cardiac troponin T was increased in 31 of 68 patients with heart failure, the positive rate of cardiac troponin T was (66.7%) higher than that of cardiac function Ⅱ (8.6%), (P <0.05). The detection rate of cardiac troponin T in patients with grade IV heart function (100%) was significantly higher than that in patients with grade III heart function (P <0.05). Long-term follow-up of 68 patients with heart failure was followed up for 14 ± 6 months. Long-term cardiac events in cardiac troponin T normal group were 16 cases, and long-term cardiac events in elevated group were 33 cases (P <0.01). CONCLUSION: The greater the rate of cardiac dysfunction, the greater the detection rate of cardiac troponin T, the serum cardiac troponin T is not only a sensitive marker of myocardial injury in patients with heart failure, but also an independent predictor of long-term cardiac events.