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目的 观察托吡酯单药或添加治疗治疗小儿癫疒间。方法 观察部分性发作及继发性全身性发作 17例 ,Lennox Gastaut综合征 31例 ,West综合征 18例 ,对其中已应用传统抗癫疒间 药物治疗控制不理想的病例添加托吡酯治疗 ,而对新诊断病例应用托吡酯单一治疗 ,进行自身对照的开放性研究。结果 ①托吡酯治疗小儿癫疒间6 6例 ,平均疗程 6个月 ,其总的疗效为发作减少≥ 5 0 %占 48例 (72 .7% ) ,发作减少≥ 75 %占 36例 (5 4.5 % ) ,发作控制 2 7例 (40 9% )。②托吡酯治疗部分性发作及继发性全身性发作 17例发作减少≥ 5 0 %为 15例 (88% ) ,发作减少≥ 75 %为 11例 (5 1.6 % ) ,发作消失为 9例 (5 2 .9% ) ;Lennox Gastaut综合征组 31例发作减少≥ 5 0 %为 2 0例(6 4.5 % ) ,发作减少≥ 75 %为 16例 (5 1.6 % ) ,发作消失为 12例 (38.7% ) ;West综合征组 18例发作减少≥ 5 0 %为13例 (72 % ) ,发作减少≥ 75 %为 9例 (5 0 0 % ) ,发作消失为 6例 (33.3% )。③添加托吡酯治疗对卡马西平和丙戊酸钠的添加治疗前后的血浓度没有明显影响。④不良反应 :嗜睡 14例 (2 1.2 % )、反应淡漠 4例 (6 .0 % )、纳差 17例 (2 5 .7% )、类暑热症 4例 (6 .0 % )。结论 托吡酯对部分性发作及继发性全身性发作、Lennox Gasta
Objective To observe the topiramate alone or add to the treatment of pediatric epilepsy. Methods 17 cases of partial seizures and secondary generalized seizures were observed, 31 cases of Lennox Gastaut syndrome and 18 cases of West syndrome. Topiramate was used in those cases in which traditional anti-epileptic drugs were not well controlled. Newly Diagnosed Cases Topiramate monotherapy for open-label, self-controlled study. Results ① topiramate treatment of pediatric epilepsy 6 6 cases, the average course of 6 months, the overall effect of the attack was reduced ≥ 50% of the episodes accounted for 48 cases (72.7%), episodes of 75% reduction in 36 cases (4.5 %), Seizure control in 27 cases (40 9%). ② topiramate treatment of partial seizures and secondary systemic attacks in 17 cases of onset reduced ≥ 50% for 15 cases (88%), seizure reduction ≥ 75% for 11 cases (5 1.6%), seizures disappeared in 9 cases (5 The incidence of seizures disappeared in 12 patients (38.7%) in the Lennox Gastaut syndrome group. The number of episodes decreased by 50% (20.5%) in the Lennox Gastaut syndrome group (16.5% In the West syndrome group, there were 13 cases (72%) reduction of onset of attack ≥ 50% in 18 cases, 9 cases (100%) in ≥ 75% reduction in seizures and 6 cases (33.3%) in seizure disappearance. ③ Add topiramate treatment of carbamazepine and sodium valproate before and after treatment did not significantly affect the blood concentration. ④ adverse reactions: lethargy in 14 cases (2 1.2%), indifferent response in 4 cases (6. 0%), anorexia in 17 cases (25.7%), 4 cases of type heat syndrome (6.0%). Conclusion Topiramate on the partial seizures and secondary systemic attacks, Lennox Gasta