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背景:糖耐量低减发病主要与遗传和环境因素有关,环境因素包括摄入热量过多和肥胖等。胰岛素抵抗是其主要发病机制之一。目的:探讨糖耐量低减患者的红细胞胰岛素酶活性(erythrocytesinsuli-naseactivity,EIA)与胰岛素抵抗的关系,为运动改善糖耐量低减患者的胰岛素抵抗提供理论支持。设计:以IGT患者为研究对象,以正常糖耐量的成年人为对照组的观察对比研究。单位:一所军医大学医院的内分泌科。对象:本研究于2001-01/2003-04在第一军医大学南方医院内分泌科完成。随机抽取住院和门诊的糖耐量低减患者50例,男26例,女24例,年龄(52±7)岁。纳入标准:符合WHO1999年口服葡萄糖耐量实验(OGTT)的糖耐量低减诊断标准,心、肝、肾功能和血常规均在正常范围,且未使用任何抗糖尿病药物者。排除标准:患肝脏、肾脏疾患、感染、恶性肿瘤、冠心病、脑血管意外和结缔组织疾病者。根据是否合并空腹血糖异常将糖耐量低减患者分为合并空腹血糖异常的糖耐量低减1组,共20例,男9例,女11例;单纯餐后高血糖未合并空腹血糖异常的糖耐量低减2组,共30例,男17例,女13例。20例正常糖耐量的成年人作为对照组,男女各10例,年龄(48±12)岁。方法:用放射酶分析法检测所有研究对象的EIA,同时检测患者的血糖、血清胰岛素和糖基化血红蛋白,并计算?
Background: The incidence of impaired glucose tolerance is mainly related to genetic and environmental factors, including environmental factors such as excessive intake of calories and obesity. Insulin resistance is one of the main pathogenesis. Objective: To investigate the relationship between erythrocytesinsul-nase activity (EIA) and insulin resistance in patients with impaired glucose tolerance and provide theoretical support for exercise-induced insulin resistance in patients with impaired glucose tolerance. DESIGN: A comparative study of IGT patients with normal glucose tolerance in adults as control group. Unit: Department of Endocrinology, a Military Medical University Hospital. PARTICIPANTS: This study was performed in Department of Endocrinology, Nanfang Hospital, First Military Medical University from January 2001 to April 2003. 50 randomly selected inpatients and outpatients with impaired glucose tolerance, 26 males and 24 females, aged 52 ± 7 years. Inclusion criteria: In line with WHO diagnostic criteria for impaired glucose tolerance of OGTT (1999), heart, liver, kidney function and blood tests are in the normal range and no antidiabetic drugs are used. Exclusion criteria: liver, kidney disease, infection, cancer, coronary heart disease, cerebrovascular accident and connective tissue disease. Patients with impaired glucose tolerance were divided into two groups according to whether they had impaired fasting glucose (IGT) or not: one group with 20 cases (9 males and 11 females), and a group with simple fasting plasma glucose Endurance low 2 groups, a total of 30 cases, 17 males and 13 females. 20 normal glucose tolerance adults as a control group, 10 males and 10 females, aged (48 ± 12) years old. Methods: The EIA of all subjects was examined by radioimmunoassay and the patients’ blood glucose, serum insulin and glycosylated hemoglobin were measured simultaneously and calculated.