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目的:探讨USMM联用技术在丹参活性成分提取分离中的应用。方法:采用SFE-CO2提取分离丹参酮类脂溶性成分,超声提取丹参酚酸类水溶性成分,膜分离与大孔树脂纯化丹参水提物,以丹参活性成分的转移率及纯度为考察指标,探索USMM技术在丹参提取分离中的可行性。结果:丹参SFE-CO2萃取工艺稳定、可行;丹参SFE渣超声提取物丹参酚酸类成分提取率高;大孔树脂纯化技术能提高丹参活性成分的纯度;膜分离及膜分离与大孔树脂技术联用对丹参酚酸的纯化工艺还有待进一步研究。结论:USMM技术应用于丹参活性成分提取分离基本可行。
OBJECTIVE: To investigate the application of USMM in the extraction and separation of the active components of Salvia miltiorrhiza. Methods: The fat-soluble components of tanshinone were isolated by SFE-CO2 extraction, the water-soluble components of salvia miltiorrhiza Bunge was extracted by ultrasonic extraction, the water extract of Salvia miltiorrhiza was purified by membrane separation and the macroporous resin. The transfer rate and purity of the active components of Salvia miltiorrhiza were investigated. Feasibility of USMM Technique in Salvia Miltiorrhiza Extraction and Separation. Results: The SFE-CO2 extraction process of Salvia miltiorrhiza was stable and feasible. The extraction rate of Salvia miltiorrhiza SFE-CO2 ultrasonic extract was high. The purification of macroporous resin could improve the purity of active ingredient of Salvia miltiorrhiza. Membrane separation, membrane separation and macroporous resin technology The purification of salvianolic acid with the process remains to be further studied. Conclusion: USMM technology applied to the active ingredient of Salvia extraction and isolation is feasible.