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从埃塞俄比亚鼠尾草 Salvia aetihiopis根中获得一种 O-萘醌二萜类化合物aethiopinone,对该化合物及其2个半合成衍生物进行丁毒性、抗炎、止痛、解热和止血活性的研究。结果表明,aethiopinone(1)及其衍生物(2,3)可有效地抑制角叉菜胶引起的水肿的形成,(1)、(2)小鼠剂量为100mg/kg。在 TPA 诱导的耳肿模型中,3种化合物可有效地降低由佛波酯诱导产生的小鼠耳肿
An O-naphthoquinone diterpenoid, aethiopinone, was obtained from the root of Salvia aetihiopis in S. edulis, and its toxicity, anti-inflammatory, analgesic, antipyretic, and hemostatic activities were studied for this compound and its 2 semi-synthetic derivatives. The results showed that aethiopinone (1) and its derivatives (2,3) can effectively inhibit the formation of carrageenan-induced edema, (1), (2) mouse dose of 100mg/kg. In the TPA-induced ear swelling model, three compounds effectively reduced the ear swelling induced by phorbol ester in mice.