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利用活性结构拼接原理,以2-苯并咪唑乙腈、亚硝酸钠、氯乙酰吗啉、卤代烃等为原料,经过肟化、取代和醚化等三步反应合成了一系列新型的[1-(4-吗啉基)羰基亚甲基苯并咪唑-2-基]氰基甲酮肟醚(4a~4h),其结构经IR,NMR,MS和元素分析确认.初步生物活性测试结果表明,部分化合物对生菜灰霉菌和番茄菌核菌有较高的抑制活性,与对照药剂多菌灵相比,含4-氟苄基或4-氯苄基的化合物4e,4f活性优异.
Using the principle of active structure splicing, a series of novel [1 (1) -hydroxybenzothiazoles were synthesized by such three steps as oximation, substitution and etherification using 2-benzimidazole acetonitrile, sodium nitrite, chloroacetylmorpholine and halogenated hydrocarbons as raw materials The structure was confirmed by IR, NMR, MS and elemental analysis. Preliminary bioassay results The results showed that some of the compounds showed high inhibitory activity against Botrytis cinerea and Sclerotinia sclerotiorum, and the compounds 4e and 4f containing 4-fluorobenzyl or 4-chlorobenzyl were superior to the control agent carbendazim.