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以低硒（Ｓｅ）低维生素Ｅ（ＶＥ）的克山病病区粮饲养大鼠１０周，用腹腔注射亚硝酸盐引起急性缺氧的方法，观察花生四烯酸代谢及其主要产物水平的变化。结果表明，病区粮组大鼠磷脂酶Ａ２活力、花生四烯酸含量、血栓素水平、血栓素／前列环素比值增高；前列环素水平、抗氧化酶活力降低；补Ｓｅ和ＶＥ可使上述变化逆转。结果提示，花生四烯酸代谢紊乱、抗氧化能力降低，是亚硝酸钠与Ｓｅ和ＶＥ缺乏协同引起心肌损害的作用环节。
Rats in Keshan disease group with low selenium (Se) low vitamin E (VE) were fed for 10 weeks. Acute hypoxia was induced by intraperitoneal injection of nitrite to observe the metabolism of arachidonic acid and the level of its major products Variety. The results showed that phospholipase A2 activity, arachidonic acid content, thromboxane level and thromboxan / prostacyclin ratio in wistar rats increased; prostacyclin levels and antioxidant enzyme activity decreased; Se and VE The above changes are reversed. The results suggest that arachidonic acid metabolism disorders, reduced antioxidant capacity, is a synergistic effect of sodium nitrite and Se and VE cause myocardial damage.