Chitosan tubes enriched with fresh skeletal muscle fibers for delayed repair of peripheral nerve def

• 作 者: Alessandro Crosio Benedetta El
• 机 构: DepartmentofOrthopedicsandTraumatologyII-SurgeryforHandandUpperLimb-AOUCittà,dellaSaluteedellaSc
• 出 处: 中国神经再生研究:英文版
• 发表日期: 2019年6期
• 关键词: tubulization Schwann cells SCAFFOLD tissue engineering NERVE reconstruction morp
• 基金项目: the European Community’s Seventh Framework Programme(FP7-HEALTH-2011),No.278612(to SG),Compagnia di San Paolo,No.D86D15000100005,InTheCure project(to SR).

Nerve regeneration after delayed nerve repair is often unsuccessful.Indeed,the expression of genes associated with regeneration,including neurotrophic and gliotrophic factors,is drastically reduced in the distal stump of chronically transected nerves;more