论文部分内容阅读
目的研究三维适形放射治疗(3D-CRT)食管癌的近期疗效和治疗反应。方法选择85例食管癌患者,其中男性55例,女性30例;年龄40～87岁,平均年龄64.64岁。分为3D-CRT组和常规放射治疗组。3D-CRT组:40例;常规放射治疗组:45例。放射治疗总剂量均为60～66Gy,常规分割,每次2Gy,5次/周,6～7周完成。结果 3D-CRT组和常规放射治疗组总有效率(CR+PR)分别为97.50%、82.20%,差异有统计学意义(P<0.05)。3D-CRT组和常规放射治疗组的1、2、3年局部控制率分别为72.6%、56.8%、48.4%和60.9%、36.3%、28.6%,差异有统计学意义(P<0.05)。3D-CRT组和常规放射治疗组的1、2、3年生存率分别为68.5%、49.5%、38.0%和51.8%、32.3%、16.4%,差异有统计学意义(P<0.05)。两组急性放射性气管炎、放射性食管炎差异均无统计学意义(P>0.05)。结论 3D-CRT食管癌能提高局部控制率和生存率,近期反应和远期反应均可耐受。
Objective To study the short-term effect and response of three-dimensional conformal radiotherapy (3D-CRT) esophageal cancer. Methods 85 cases of esophageal cancer patients, including 55 males and 30 females; aged 40 to 87 years, with an average age of 64.64 years. Divided into 3D-CRT group and conventional radiotherapy group. 3D-CRT group: 40 cases; conventional radiotherapy group: 45 cases. The total dose of radiation therapy are 60 ~ 66Gy, conventional segmentation, each 2Gy, 5 times / week, 6 to 7 weeks to complete. Results The total effective rate (CR + PR) in 3D-CRT group and conventional radiotherapy group was 97.50% and 82.20%, respectively, with significant difference (P <0.05). The local control rates at 1, 2 and 3 years in 3D-CRT group and conventional radiotherapy group were 72.6%, 56.8%, 48.4% and 60.9%, 36.3% and 28.6%, respectively. The difference was statistically significant (P <0.05). The 1-, 2- and 3-year survival rates of 3D-CRT group and conventional radiotherapy group were 68.5%, 49.5%, 38.0% and 51.8%, 32.3% and 16.4%, respectively. The difference was statistically significant (P <0.05). There was no significant difference between the two groups in acute radiation tracheitis and radiation esophagitis (P> 0.05). Conclusion 3D-CRT esophageal cancer can improve the local control rate and survival rate, the recent response and long-term response can be tolerated.