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目的探讨检测糖尿病肾病患者血清胱抑素C(Cys-C)水平的临床意义。方法根据24-h尿微量白蛋白排泄率(UAE),将2型糖尿病(T2DM)患者80例分为无蛋白尿(A组,36例,UAE<30mg/L)和微量蛋白尿(B组,44例,UAE 30-300mg/L)两组,另选30例体检健康者作为对照(C组),采用免疫比浊法检测血清Cys-C,生化分析仪检测血肌酐(SCr)。结果 A组血清Cys-C和SCr分别为(0.95±0.46)mg/L和(95.54±16.21)μmol/L,明显低于B组的(1.14±0.73)mg/L和(101.42±13.46)μmol/L(P<0.05);A、B组血清Cys-C和SCr均明显高于C组的(0.63±0.07)mg/L和(55.54±10.05)μmol/L(P<0.05)。A组血清Cys-C和SCr异常检出率均明显低于B组(19.44%vs.40.91%和2.78%vs.9.09%)(P<0.05);A、B组Cys-C异常检出率均明显高于SCr异常检出率(P<0.05)。结论糖尿病肾病患者血清Cys-C水平升高;与SCr比较,检测血清Cys-C更有助于糖尿病肾病的早期诊断。
Objective To investigate the clinical significance of serum cystatin C (Cys-C) in patients with diabetic nephropathy. Methods According to the urinary albumin excretion rate (UAE) of 24-h, 80 patients with type 2 diabetes (T2DM) were divided into no proteinuria (group A, 36 cases, UAE <30mg / L) and microalbuminuria , 44 cases (UAE 30-300mg / L) and 30 healthy controls were selected as control group (C). Serum Cys-C was detected by immunoturbidimetry. Serum creatinine (SCr) was detected by biochemical analyzer. Results The serum Cys-C and SCr in group A were (0.95 ± 0.46) mg / L and (95.54 ± 16.21) μmol / L respectively, which were significantly lower than those in group B (1.14 ± 0.73) mg / L and (101.42 ± 13.46) μmol /L(P<0.05);A, B group serum Cys-C and SCr were significantly higher than those in C group (0.63 ± 0.07) mg / L and (55.54 ± 10.05) μmol / L (P <0.05). The positive rates of Cys-C and SCr abnormalities in group A were significantly lower than those in group B (19.44% vs.40.91% and 2.78% vs.9.09%, respectively) (P <0.05) Were significantly higher than the abnormal detection rate of SCr (P <0.05). Conclusions Serum Cys-C levels are elevated in patients with diabetic nephropathy. Compared with SCr, serum Cys-C is more helpful for the early diagnosis of diabetic nephropathy.