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凋亡在细胞的增生和死亡的平衡中起重要作用,诸如它可以消除体内不能识别“自体”与“非己”的免疫监视细胞,防止发生自身免疫性疾病;维持人体器官的正常大小,皮肤、黏膜的正常更新等,同时,凋亡也与肿瘤的发生、转归及抗肿瘤药物的治疗结果有密切联系。近年来,凋亡与白血病的关系已成为研究的热点。1凋亡概念生物体内有两种形态学和生化改变截然不同的细胞死亡方式,其一为坏死,属“事故性”或“病理性”死亡;其二为细胞凋亡,属“程序性”或“生理性”死亡,既细胞程序性死亡(PCD),由英国爱丁堡大学生物学家Kerr首先提出,他早在1972年就描述了形态学上不同于坏死性细胞的另一种细胞死亡方式,并称之为凋亡细胞死亡。
Apoptosis plays an important role in the balance between cell proliferation and death, such as its ability to eliminate immune surveillance cells in the body that do not recognize “autologous ” and “nonself ”, to prevent the occurrence of autoimmune diseases; Normal size, normal skin and mucosal renewal, etc. At the same time, apoptosis is also closely related to the occurrence and prognosis of tumors and the results of the treatment of anticancer drugs. In recent years, the relationship between apoptosis and leukemia has become a research hotspot. Apoptosis Concept There are two morphological and biochemical changes in living organisms in a completely different way of cell death, one of which is necrosis, is an “accidental” or “pathological” death; the second is apoptosis, “Procedural” or “physiological” death, both programmed cell death (PCD), first proposed by biologist Kerr at the University of Edinburgh, England, as early as 1972, described the morphological differences from necrosis Another way of cell death is cell death, which is called apoptotic cell death.