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本试验选用健康绵羊１１只，采用人工置核、注射不同菌型Ｅ．ｃｏｌｉ等模拟措施，并通过对施术动物不同时间引流胆汁的理化指标及胆囊病理组织学变化进行的检测和观察，探讨人工培黄技术中有关模拟措施对胆囊内环境的影响及该环境的改变与牛黄形成的相关关系。实验发现，在培黄期间胆汁ｐＨ、粘度升高，胆固醇含量升高，而胆汁酸含量下降；同时施术动物胆囊表现为程度不等的粘膜上皮变性、脱落，粘膜下腺体增生或腺上皮变性、毁坏。结果表明，植入适宜的载体是形成牛黄的基础，注入Ｅ．ｃｏｌｉ造成胆囊适度感染在人工培黄中必不可少，而培黄动物胆囊壁固有层内腺体的增生及炎症反应是胆汁内粘蛋白增多、胆汁粘度升高的组织学基础。
In this experiment, 11 healthy sheep were selected and artificial nucleation and injection of different bacterial types were used. Coli and other simulation measures, and through the physical and chemical indicators of gallbladder drainage and the histopathological changes of the gallbladder at different times of the operation animals, to explore the impact of artificial measures on the gallbladder environment and the changes in the environment Relationship with bezoar formation. It was found that during bacteriostasis, the pH and viscosity of bile increased during the culture, and the cholesterol content increased while the bile acid content decreased. At the same time, the gallbladder of animals was treated as varying degrees of degeneration and shedding of submucosal epithelium, submucosal gland proliferation, or glandular epithelium. Degeneration, destruction. The results showed that the appropriate carrier for implantation was the basis for the formation of bezoar and the injection of E. The gallbladder infection caused by coli is indispensable in the artificial cultivation of yellow, and the proliferative and inflammatory reaction of the inner gallbladder wall in the gallbladder wall is the histological basis for increased bile mucin and increased bile viscosity.