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本文测定了39例男性十二指肠溃疡活动期及其中10例疤痕期患者的血清睾酮(T)、雌二醇(E_2)、泌乳素(PRL),黄体生成素(LH)和卵泡刺激素(FSH)浓度。结果表明:活动期患者血清T、E_2、LH、FSH 均明显低于对照组(P 均<0.05)。且E_2与T;T 与LH 呈正相关(r=0.58,P<0.05;r=0.44,P<0.05)。疤痕期患者上述四项指标较治疗前明显升高(P 均<0.05),与对照组相比无显著差异(P 均>0.05)。作者认为溃疡病患者活动期血清性激素浓度降低的主要原因似乎与垂体-性腺轴功能的保护性抑制有关。
In this study, the serum levels of testosterone (T), estradiol (E2), prolactin (PRL), luteinizing hormone (LH) and follicle-stimulating hormone in 39 male patients with duodenal ulcer and 10 patients with scars were measured. (FSH) concentration. The results showed that the serum levels of T, E_2, LH and FSH in patients with active stage were significantly lower than those in control group (all P <0.05). There was a positive correlation between E_2 and T; T and LH (r = 0.58, P <0.05; r = 0.44, P <0.05). The above four indexes in patients with scar stage were significantly higher than those before treatment (all P <0.05), there was no significant difference compared with the control group (all P> 0.05). The authors believe that the main reason for the decreased serum levels of sex hormone in patients with ulcer disease appears to be related to the protective inhibition of pituitary-gonadal axis function.