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目的研究南宁市2 000例0~6岁儿童(男1 298名,女702名)血Pb含量及与Zn、Cu、Fe、Ca、Mg含量的关系。方法用原子吸收分光光度法测定血Pb、Zn、Cu、Fe、Ca、Mg含量,为便于与国内外文献比较,以血Pb浓度≥100μg/L为铅中毒判定标准。结果学龄前儿童平均血铅水平(BLL)为(52.11±45.10)μg/L,铅中毒检出率为6.60%。以4~岁儿童BLL、铅中毒检出率最高。男童BLL高于女童,血Fe含量低于女童,差异有统计学意义(P<0.05)。BLL 50~μg/L组与BLL<50μg/L组比较,血Zn、Fe含量较高,Ca含量较低,差异有统计学意义(P<0.05)。相关性分析显示,BLL<50μg/L组BLL与血Zn、Cu、Fe含量及年龄呈正相关,与Ca含量呈负相关;BLL>150μg/L组BLL与血Mg含量呈正相关。结论儿童BLL和血Fe水平具有性别差异。低水平Pb暴露可引起体内Zn、Cu、Fe、Ca、Mg元素代谢及平衡紊乱。
Objective To study the relationship between the content of Pb and the contents of Zn, Cu, Fe, Ca and Mg in 2 000 children aged 0-6 years in Nanning (1 298 males and 702 females). Methods The contents of Pb, Zn, Cu, Fe, Ca and Mg in blood were determined by atomic absorption spectrophotometry. To compare with the literature at home and abroad, Pb concentration of Pb ≥ 100 μg / L was taken as the criterion of lead poisoning. Results The average blood lead level (BLL) of pre-school children was (52.11 ± 45.10) μg / L, and the detection rate of lead poisoning was 6.60%. To children aged 4 ~ BLL, the highest detection rate of lead poisoning. The BLL in boys was higher than that in girls, and the Fe content in boys was lower than that in girls. The difference was statistically significant (P <0.05). Compared with BLL 50μg / L group, BLL 50 ~ μg / L group had higher levels of Zn, Fe and Ca than those of BLL <50μg / L group (P <0.05). Correlation analysis showed that the BLL in BLL group was positively correlated with the content and age of Zn, Cu and Fe, but negatively correlated with the content of Ca in BLL <50μg / L group, and positively correlated with the content of BLL in BLL> 150μg / L group. Conclusions There is a gender difference in children with BLL and blood Fe levels. Low levels of Pb exposure can cause Zn, Cu, Fe, Ca, Mg metabolism and balance disorders in the body.