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地塞米松是一种合成的糖皮质激素,具有抗炎、抗过敏、抗风湿、免疫抑制等作用,广泛用于各种类型的高原病,是治疗高原脑水肿的首选药物,高剂量的地塞米松可以预防急性高山病,同时也用于各类急性高原病治疗。地塞米松主要通过肝脏代谢,由肝脏中的CYP3A4介导。本文就高原病的分类与药物治疗及地塞米松在治疗高原病中的应用及对肝脏影响进行了综述。
Dexamethasone is a synthetic glucocorticoid with anti-inflammatory, anti-allergic, antirheumatic, immunosuppressive and other effects, is widely used in various types of altitude sickness, is the treatment of high altitude brain edema drug of choice, high dose Dexamethasone can prevent acute mountain sickness, but also for the treatment of various types of acute altitude sickness. Dexamethasone is primarily metabolized by the liver and is mediated by CYP3A4 in the liver. This article reviews the classification of high altitude sickness and medical treatment, the application of dexamethasone in the treatment of high altitude disease and its impact on the liver.