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据报道美国Goeddel D V等人于1981年11月16日著文宣布:首次成功地鉴定出干扰素珈玛蛋白(IFN—γ)基因,并利用基因重组技术获得了由大肠杆菌和培养中的猴细胞分别产生的人干扰素珈玛蛋白。经测定与人白细胞产生的IFN—γ在免疫学、化学等特性方面相同。他们测得基因重组所取得的IFN—γ的分子量为17100,与同期Yip,Y K等人报告的结果一致。Goeddel D V等人研究清楚了IFN—γ蛋白的氨基酸顺序,并证明IFN—γ基因位点内含有内含子(Intron),而近20年来广为人们所知的IFN—α和IFN—β基因区则不含内含子。
It is reported that Goeddel DV and others in the United States in November 16, 1981 article published: the first successful identification of interferon gamma protein (IFN-gamma) gene and the use of gene recombination technology obtained by the E. coli and cultured monkey The cells produced human interferon gamma protein, respectively. It was determined that IFN-γ produced by human leukocytes is the same in immunological, chemical and other properties. They measured that the molecular weight of IFN-γ obtained by genetic recombination was 17,100, consistent with the results reported by Yip and YK et al. Goeddel DV et al. Studied the amino acid sequence of IFN-γ protein and demonstrated that the IFN-γ gene locus contains introns (Intron), while the genes of IFN-α and IFN-β, which are widely known for nearly 20 years Areas do not contain introns.