Inclusion Behavior of Dimer β-CyclodextrinBridged with Aspartic Acid Derivative

• 出 处: Chinese Chemical Letters
• 发表日期: 2001年02期
• 关键词: equiv supramolecular guest bridged Fmoc isotherm dissociation minutes dimer affi

The (β-cyclodextrin (CD) dimer bridged with aspartic acid (ASP) derivative, FITC-ASP(NH-(-CD)2 (Host, FITC=fluorescein-4-isothiocyanate), was synthesized. Fluorescence polarization study showed that the novel host formed an inclusion compound, [FITC-ASP(NH-(-CD)2]ATA, for which Kd was determined to be 5.0×10-6 mol/L by Beacon 2000 Analyzer, when ATA (Guest) = Adm-Trp-Arg-Arg-NH2 (Adm = 1-adamantanecarboxylic acid, Trp = tryptophan, Arg = arginine), where Kd is the dissociation constant in aqueous solution at 298 K.

Fluorescence polarization study showed that the (β-cyclodextrin (CD) dimer bridged with aspartic acid (ASP) derivative, FITC-ASP ATA, for which Kd was determined to be 5.0 x 10-6 mol / L by Beacon 2000 Analyzer, when ATA (Guest) = Adm- Trp-Arg-Arg-NH2 (Adm = 1-adamantanecarboxylic acid, Trp = tryptophan, Arg = arginine) where Kd is the dissociation constant in aqueous solution at 298K.