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应用抗胎盘型谷胱甘肽S—转移酶(GST—π)单克隆抗体,PAP免疫组化染色,对103例原发性肺癌(包括鳞癌31例,腺癌33例,腺鳞癌6例,大细胞癌4例,小细胞癌14例,类癌11例,肺泡细胞癌3例及透明细胞癌1例)进行了检测。结果发现除类癌和小细胞癌外,GST—π在肺癌阳性率高达89.2％(68/78),18例肺良性病变和10例正常肺中,仅1例胎肺呈阳性表达,其余皆阴性。可见GST—π的免疫组化检测可作为肺癌诊断,鉴别诊断的一项新指标。
Using anti-placental glutathione S-transferase (GST-π) monoclonal antibody, PAP immunohistochemical staining for 103 cases of primary lung cancer (including 31 cases of squamous cell carcinoma, 33 cases of adenocarcinoma, and 6 of adenosquamous carcinoma) For example, 4 cases of large cell carcinoma, 14 cases of small cell carcinoma, 11 cases of carcinoid, 3 cases of alveolar cell carcinoma, and 1 case of clear cell carcinoma were examined. The results showed that in addition to carcinoid and small cell carcinoma, the positive rate of GST-π in lung cancer was as high as 89.2% (68/78). In 18 lung benign lesions and 10 normal lungs, only one fetal lung was positively expressed, and the others were all positive. negative. It can be seen that GST-π immunohistochemistry can be used as a new indicator for the diagnosis and differential diagnosis of lung cancer.