己基可可碱对兔耳瘢痕组织的作用

• 作 者: 吴美莲 罗少军 汤少明 粱莉 张刚
• 机 构: 广东医学院附属医院整形外科研究所,广东医学院附属医院整形外科研究所,广东医学院附属医院整形外科研究所,广东医学院附属医院整形外科研究所,广东医学院附属医院整形外科研究所 524001湛江,524001
• 出 处: 中华医学美学美容杂志
• 发表日期: 2005年03期
• 关键词: 己基可可碱 增生性瘢痕 动物模型

目的观察己基可可碱对兔耳增生性瘢痕组织的影响。方法建立兔耳增生性瘢痕动物模型,21d后瘢痕局部注射不同浓度的己基可可碱或生理盐水,49d后观察药物对瘢痕增生指数(hyper trophicindex,HI)的影响及采用图像系统分析瘢痕组织中成纤维细胞数量和胶原含量的变化。结果治疗组中HI与药物浓度呈负相关(P<0.05),治疗组瘢痕组织中成纤维细胞数量与胶原含量均明显减少,呈剂量效应关系;与生理盐水对照组比较,差异有统计学意义(P<0.01)。结论己基可可碱能抑制瘢痕组织中成纤维细胞增殖,并使胶原合成减少,从而抑制兔耳增生性瘢痕组织增生,有望成为防治增生性瘢痕的新药物。

Objective To observe the effect of caproic theobromine on hypertrophic scars in the ear of rabbits. Methods Rabbit ear hypertrophic scar animal model was established. After 21 days, different concentrations of pentoxifylline or normal saline were injected into the scars. After 49 days, the hyper trophicindex (HI) of the scar was observed. Changes in the number of fibroblasts and collagen content. Results In the treatment group, HI was negatively correlated with the drug concentration (P <0.05), and the number of fibroblasts and collagen in the scar tissue of the treatment group were significantly reduced, showing a dose-response relationship; compared with the saline control group, the difference was statistically significant (P <0.01). Conclusion Hexyl theobromine can inhibit the proliferation of fibroblasts in scar tissue and reduce the collagen synthesis, thus inhibiting the hyperplasia of hypertrophic scars in rabbit ears, which is expected to become a new drug for the prevention and treatment of hypertrophic scars.