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目的:观察急性心肌梗死(AMI)患者血浆N-proBNP(N-terminal pro-B-type natriuretic peptide)的水平与不同部位梗死急性期左室功能的关系,探讨其临床意义。方法:126例AMI患者分为:A组,前、侧壁组;B组,下、后壁组。所有患者用放射免疫法测定血浆N-proBNP浓度并行超声心动图检查评价室壁运动和心功能。结果:急性期A组室壁运动障碍较B组明显,N-proBNP水平高,与射血分数呈负相关。结论:急性期N-proBNP对于急性期心功能状态及心室重构有重要的预测作用。
Objective: To investigate the relationship between plasma N-terminal pro-B-type natriuretic peptide (N-terminal pro-B-type natriuretic peptide) and left ventricular function in acute myocardial infarction patients with acute myocardial infarction (AMI) and to investigate its clinical significance. Methods: 126 AMI patients were divided into: A group, anterior and lateral wall group; B group, inferior and posterior wall group. All patients were measured by radioimmunoassay of plasma N-proBNP concentration and echocardiography examination of ventricular wall motion and cardiac function. Results: Acute wall motion impairment in group A was more obvious than that in group B, and the level of N-proBNP was high, which was negatively correlated with ejection fraction. CONCLUSION: Acute N-proBNP plays an important role in predicting cardiac function and ventricular remodeling during acute phase.