论文部分内容阅读
目的探讨肝癌高发区原发性肝癌的家族发病情况。方法采用调查问卷的方法,对广西隆安县队列研究中65例确诊为原发性肝癌患者的家系按一、二级亲属进行调查,核实其家族内原发性肝癌的发病情况,比较家族人群的肝癌发病率。结果共调查家属成员1167人,先证者中有肝癌家族史占60.00%,患者亲属发病率(6.17%)高于该地区一般人群的肝癌发病率。一级亲属患病率(14.84%)高于二级亲属患病率(3.03%)。发生肝癌例数最多的一个家族有7例,父亲中肝癌的发病率最高,男性患病率高于女性,乙型肝炎病毒(HBV)DNA阳性者有肝癌家族史的高于HBVDNA阴性者。结论原发性肝癌与HBV感染和肝癌家族史有密切关系,肝癌家族史的遗传模式复杂。
Objective To investigate the familial incidence of primary liver cancer in high incidence area of liver cancer. Methods A questionnaire was used to investigate the incidence of primary liver cancer in 65 pedigrees diagnosed as primary hepatocellular carcinoma in Longan County of Guangxi according to primary and secondary relatives, The incidence of liver cancer. Results A total of 1167 family members were investigated. Among the probands, the family history of HCC accounted for 60.00%. The incidence of relatives (6.17%) was higher than that of the general population in the region. The prevalence of first-degree relatives (14.84%) was higher than that of second-degree relatives (3.03%). One of the most frequent cases of HCC was found in seven families. The incidence of HCC was the highest in fathers, and the prevalence was higher in males than in females. Hepatitis B virus (HBV) DNA positive patients had a higher HCC family history than those with negative HBVDNA. Conclusions Primary liver cancer is closely related to HBV infection and family history of HCC. The genetic pattern of HCC family history is complex.