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自1991年8月～1994,年6月,我院收治肺癌脑转移42例,单纯常规放疗28例,放疗同时应用EP方案化疗14例,分析报道如下。 1 材料与方法 1.1 一般资料 42例中,男18例,女24例,中位年龄56岁(35～68岁),均无它处转移,胸内病灶未控8例,病理类型:鳞癌12例,腺癌12例,小细胞癌12例,不能分类6例,单发脑转移22例,多发脑转移20例。单纯放疗组和同时化疗组间病例分布无差异。 1.2 治疗方法 全组病例均接受60℃α线外放疗,全颅放疗38～50GY/19～25次/4～5周,单发脑转移者缩野局部加重至D_T50～60GY。其中28例单纯放疗,14例在放疗20～30GY时,同时接受EP方案化疗,DDP40mg/m~2第1～3天,并加用水化St,VP_(16)100mg第4～8天,21天为1周期,连用2周期。
From August 1991 to 1994 and June of the same year, 42 cases of brain metastases from lung cancer were treated in our hospital, 28 cases were treated with conventional radiotherapy alone, and 14 cases were treated with radiotherapy at the same time with EP regimen. The analysis was reported as follows. 1 Materials and methods 1.1 General information 42 cases, 18 males and 24 females, median age 56 years (35 to 68 years old), there is no metastasis, 8 cases of uncontrolled chest lesions, pathological type: squamous cell carcinoma In 12 cases, 12 were adenocarcinomas, 12 were small cell carcinomas, 6 were unclassifiable, 22 were single brain metastases, and 20 were multiple brain metastases. There was no difference in the distribution of cases between the single radiotherapy group and the concurrent chemotherapy group. 1.2 Treatment The whole group of patients received 60 °C α line external radiotherapy, total cranial radiotherapy 38 ~ 50GY/19 ~ 25 times / 4 ~ 5 weeks, a single brain metastases were shrinking local increased to D_T50 ~ 60GY. Among them, 28 cases received radiotherapy alone, and 14 cases received radiotherapy at the same time with 20 to 30 GY of radiotherapy. EP regimens received DDP 40 mg/m~2 for the first 1 to 3 days. Hydration of St, VP 16 (100 mg) for 4 to 8 days, 21 Day is 1 cycle, use 2 cycles.