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Brooks等于10年前首先提出了“反应性气道功能异常综合征”(RADS)的术语,系指既往无症状的健康者在一次接触高浓度的呼吸道刺激物后24小时内出现进行性的哮喘样发病伴气道高反应性者。继而Tarlo和Broder将健康人反复多次接触气道刺激物后出现上述现象称之为“刺激物诱导性哮喘”(ⅡA)。此后相继报道了80多例RADS和ⅡA,并对其发病率、病理改变和病理生理进行了探讨。美国胸科协会和加拿大胸科协会及法定委员会均承认了该类疾病。 然而,并非所有专家均认为RADS和ⅡA是真正独立的临床疾病,新近Kennedy的一篇综述颇具代表性,她认为气道高反应性可由接触非免疫原性刺激物
Brooks first proposed the term “reactive airway dysfunction syndrome” (RADS) ten years ago, referring to progressive asthma in previously asymptomatic healthy individuals within 24 hours of exposure to a high concentration of respiratory irritants Likely associated with airway hyperresponsiveness. Then Tarlo and Broder will be healthy people repeated exposure to airway irritants appear after the phenomenon called “stimulus-induced asthma” (Ⅱ A). Since then, more than 80 cases of RADS and Ⅱ A were reported, and the incidence, pathological changes and pathophysiology were discussed. The American Thoracic Society and the Canadian Thoracic Society and the Statutory Board recognize the disease. However, not all experts agree that RADS and IIA are truly independent clinical disease and a recent review by Kennedy is representative of her finding that airway hyperresponsiveness may be caused by exposure to non-immunogenic stimuli