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目的:分析利奈唑胺治疗高龄重症肺炎患者致血小板减少的特点,为高龄患者合理用药提供参考。方法:回顾性分析16例高龄重症肺炎利奈唑胺治疗的临床资料,分析其临床疗效及危险因素,总结其不良反应的发生情况。结果:男14例,女2例,年龄81-99岁,平均91.2±1.4岁。有13例(81.25%)发生血小板减少,多在用药3～7天发生,停药后恢复时间5～10天。结论:利奈唑胺治疗80岁以上重症肺炎患者血小板下降发生机率高,建议应用利奈唑胺治疗过程中密切监测血象,一旦发现血小板减少,及时停药,以免严重不良反应发生。
OBJECTIVE: To analyze the characteristics of linezolid in the treatment of elderly patients with severe pneumonia caused by thrombocytopenia, provide reference for the rational use of drugs in elderly patients. Methods: A retrospective analysis of 16 cases of elderly patients with severe pneumonia linezolid treatment of clinical data, analysis of its clinical efficacy and risk factors, summed up the incidence of adverse reactions. Results: There were 14 males and 2 females, aged 81-99 years, with an average of 91.2 ± 1.4 years. Thirteen patients (81.25%) had thrombocytopenia, mostly in medication 3 to 7 days, stopping time after recovery of 5 to 10 days. Conclusion: Linezolid treatment of patients with severe pneumonia more than 80 years of age has a high incidence of thrombocytopenia. It is recommended to monitor the blood in the process of linezolid treatment. Once thrombocytopenia is found and the drug is withdrawn in time, serious adverse reactions may occur.