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目的比较甲型肝炎减毒活疫苗与灭活疫苗的血清学免疫效果。方法筛选抗 -HAVIgG阴性 ,6 -18岁的甲肝易感人群104名 ,随机分为国产减毒活疫苗组和进口灭活疫苗组 ,免疫程序为0、6月两针法 ,于每针免疫后1个月采集静脉血 ,分离血清检测抗 -HAVIgG。结果首针免疫后抗 -HAVIgG阳转率减毒活疫苗组为80.0 %(40/50) ,灭活疫苗组为96.3 %(52/54) ,两组间差异有高度显著性(χ2=6.75,P<0.01) ;第2针免疫后抗 -HAVIgG阳转率两组均为100.0 %。结论不论应用国产甲肝减毒活疫苗或进口灭活疫苗 ,都应进行两次疫苗接种 ,才能获得较佳的预防效果
Objective To compare the serological immune effects of live attenuated hepatitis A vaccine and inactivated vaccine. Methods A total of 104 anti-HAVIgG-negative, 6-18-year-old susceptible patients were randomly divided into domestic attenuated live attenuated vaccine group and imported inactivated vaccine group. The immune procedure was 0 and 6 months. Venous blood was collected one month later and serum was tested for anti-HAVIgG. Results After the first immunization, the anti-HAV IgG positive rate of live attenuated vaccine was 80.0% (40/50) in the live vaccine group and 96.3% (52/54) in the inactivated vaccine group, with a significant difference between the two groups (χ2 = 6.75 , P <0.01). The anti-HAV IgG positive rate after the second immunization was 100.0% in both groups. Conclusion Regardless of the application of live attenuated live attenuated hepatitis A virus or imported inactivated vaccine should be twice vaccinated in order to obtain better preventive effect