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心血管疾病在维持性血液透析(MHD)患者中发生率较高,是其主要死因。N端脑钠肽前体(NT-proBNP)是由心室肌细胞合成和分泌的肽类激素,可以反映体内心肌细胞受到的容量负荷和压力负荷的大小,已广泛应用于正常人群的心血管疾病的诊断、治疗及预后评价。近年来大量研究证明,NT-proBNP也可作为监测MHD患者心血管疾病的重要生物学标志,其浓度对早期评判MHD患者心脏结构和功能异常、预测心血管事件发生及死亡、评估容量负荷等具有重要价值。
Cardiovascular disease is a high prevalence among patients with maintenance hemodialysis (MHD) and is the leading cause of death. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a peptide hormone synthesized and secreted by ventricular myocytes and can reflect the capacity load and pressure load on the cardiomyocytes in vivo. It has been widely used in the cardiovascular disease of normal population Diagnosis, treatment and prognosis evaluation. In recent years, a large number of studies have shown that NT-proBNP can also be used as an important biomarker for monitoring cardiovascular disease in patients with MHD, the concentration of cardiac MHD patients with early evaluation of cardiac structure and function abnormalities, predict cardiovascular events and death, assessment of capacity load Important value.