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目的:探讨白血病抑制因子(LIF)及其受体(LIFR)与输卵管异位妊娠的关系。方法:采用免疫组化技术检测11例非孕组和36例输卵管异位妊娠组输卵管组织中LIF和LIFR的表达水平,半定量分析其在各组间的表达差异。结果:无论是在输卵管腺上皮还是间质中,LIF在非孕组和异位妊娠组间的表达无明显差别;但是在输卵管腺上皮中,LIFR的表达异位妊娠组高于非孕组(P<0.05);而在间质中,LIFR的表达输卵管妊娠组明显低于非孕组(P<0.01)。结论:LIFR的异常表达可能与输卵管异位妊娠的发生密切相关。
Objective: To investigate the relationship between leukemia inhibitory factor (LIF) and its receptor (LIFR) and tubal ectopic pregnancy. Methods: The expression of LIF and LIFR in oviduct tissues of 11 cases of non-pregnant group and 36 cases of tubal ectopic pregnancy were detected by immunohistochemistry, and the expression of LIF and LIFR was detected by semi-quantitative analysis. Results: There was no significant difference in the expression of LIF between non-pregnant group and ectopic pregnancy in either tubal gland epithelium or interstitium. However, the expression of LIFR in ovarian gland epithelium was higher than that in non-pregnant group P <0.05). In interstitial tissue, the expression of LIFR in tubal pregnancy group was significantly lower than that in non-pregnant group (P <0.01). Conclusion: The abnormal expression of LIFR may be closely related to the occurrence of tubal ectopic pregnancy.