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A simple synthesis of highly functionalized 2,5-diaminofurans based pyrimidine derivatives from l-(carboxymefhyl)uracil via a multi-component reaction is described.The reactive 1:1 intermediate produced from the reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates was trapped at room temperature by l-(carboxymethyl)uracil derivatives to yield polyfunctionalized furan rings in fairly good yields.
A simple synthesis of highly functionalized 2,5-diaminofurans based pyrimidine derivatives from l- (carboxymefhyl) uracil via a multi-component reaction is described. Reactive 1: 1 intermediate produced from the reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates was trapped at room temperature by l- (carboxymethyl) uracil derivatives to yield polyfunctionalized furan rings in fairly good yields.