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目的探讨人类辅助生育技术治疗过程中影响卵巢储备功能减退患者控制性超促排卵的卵巢反应性的相关因素。方法回顾性分析接受IVF/ICSI治疗的、资料完整的874例卵巢储备功能减退不孕患者的所有统计学资料。结果 874例患者中卵巢低反应组347例,卵巢正常反应组527例。单因素分析显示,患者年龄、b LH水平、b FSH/b LH比值、窦卵泡数在卵巢低反应组和卵巢正常反应组间差异具有统计学意义(P<0.05)。Logistic回归分析显示,患者年龄与卵巢反应性呈负相关,窦卵泡数与卵巢反应性呈正相关,并且相关程度窦卵泡数>患者年龄。结论患者年龄和窦卵泡数对于卵巢储备功能减退患者超促排卵的卵巢反应性有预测价值,窦卵泡数敏感性优于患者年龄。
Objective To investigate the related factors of ovarian response in controlled ovarian hyperstimulation in patients with ovarian reserve deficit during the course of human assisted reproductive technology. Methods A retrospective analysis of all IVF / ICSI-treated, data complete 874 cases of ovarian reserve dysfunction in patients with all the statistical information. Results Among 874 patients, 347 cases were ovarian low response group and 527 cases were normal ovarian response group. Univariate analysis showed that the age, b LH level, b FSH / b LH ratio and the number of antral follicles in the ovarian low response group and normal ovarian response group were significantly different (P <0.05). Logistic regression analysis showed that the age of patients was negatively correlated with ovarian response, the number of antral follicles was positively correlated with ovarian response, and the degree of correlation antral follicles> age of patients. Conclusions The age of patients and the number of antral follicles have predictive value for ovarian response to superovulation in patients with ovarian reserve deficit. The number of antral follicles is superior to patients in age.