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From 1988 to 1992, 2479 volunteers were immunized by inactivated Meriones unguiclatus kidney cell (MUKC) vaccine.Their seroconversion rates of neutralizing antibody were about 90% after 3 doses of the vaccine. No side effects were found.The vaccine stored for 14 months at 4℃ still had good immnogenicity. It was shown that the vaccine was safe, effective and stable. Detailed observation was made in 75 volunteers. The results showed that the seroconversion rate by plaque reduction neutralization test in 3 doses group was higher than that in 2 doses group; but the results by reversed passive hemagglutination (RPHI),immunofluoresceuce assay (IFA) and ELISA were similar. Different immunization proce-
From 1988 to 1992, 2479 volunteers were immunized by inactivated Meriones unguiclatus kidney cell (MUKC) vaccine. The seroconversion rates of neutralizing antibodies were about 90% after 3 doses of the vaccine. No side effects were found. The vaccine stored for 14 months at It was shown that the vaccine was safe, effective and stable. Detailed observation was made in 75 volunteers. The results showed that the seroconversion rate by plaque reduction neutralization test in 3 doses group was higher than that in 2 doses group; but the results of reversed passive hemagglutination (RPHI), immunofluorescence assay (IFA) and ELISA were similar. Different immunization proce-