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目的:探讨针刺治疗在体外受精/卵胞质内单精子显微注射-胚胎移植(IVF/ICSI-ET)治疗过程中对卵巢过度刺激综合征(OHSS)的发生所产生的影响。方法:将进行IVF/ICSI-ET治疗的304例不孕症患者随机分为针刺治疗组(研究组)和对照组。采用黄体期促性腺激素释放激素激动剂(GnRH-a)长方案进行控制性超促排卵,研究组患者从控制性超促排卵第1日开始接受针刺治疗,直至胚胎移植日(取卵日不进行针刺治疗),对照组不作针刺治疗,其余同研究组。观察比较研究组和对照组促性腺激素(Gn)用量、血清雌二醇(E2)水平、OHSS发生率、获卵数、临床妊娠率和流产率等。结果:①研究组OHSS的发生率低于对照组(2.03%vs 7.33%,P<0.05);②研究组胚胎移植日血清E2水平低于对照组(P<0.05);③研究组临床妊娠率和流产率与对照组相比均无统计学差异(52.90%vs 50.74%,P>0.05;10.96%vs 10.14%,P>0.05).结论:针刺辅助治疗对降低IVF-ET治疗过程中OHSS的发生起到一定的作用。
Objective: To investigate the effect of acupuncture on ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization / intracytoplasmic sperm injection / embryo transfer (IVF / ICSI-ET). Methods: 304 infertility patients treated with IVF / ICSI-ET were randomly divided into acupuncture group (study group) and control group. Ovulation was controlled by a long protocol of Luteinizing Gonadotropin Releasing Hormone Agonist (GnRH-a). Patients in the study group received acupuncture treatment on the 1st day of controlled superovulation until embryo transfer day Not acupuncture treatment), the control group without acupuncture treatment, the rest with the study group. The levels of gonadotropin (Gn), serum estradiol (E2), incidence of OHSS, number of oocytes retrieved, clinical pregnancy rate and miscarriage rate were compared between the study group and the control group. Results: ① The incidence of OHSS in study group was lower than that in control group (2.03% vs 7.33%, P <0.05); ② The level of serum E2 in study group was lower than that in control group (P <0.05); ③ The clinical pregnancy rate (52.90% vs 50.74%, P> 0.05; 10.96% vs 10.14%, P> 0.05) .Conclusion: Acupuncture adjuvant therapy can reduce OHSS in IVF-ET treatment The occurrence of a certain role.