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目的:探讨丹参注射液联合高压氧治疗慢性肝病和肝纤维化疗效。方法:对照组采用常规护肝、降酶、退黄(甘利欣、还原型谷胱甘肽、门冬氨酸钾镁、思美泰及多种维生素等)治疗慢性肝病21 例,同时静脉滴注复方丹参注射液;高压氧组22例在上述治疗的基础上加用高压氧治疗。结果:经治疗45 天、90 天后,高压氧组血清透明质酸(HA)、Ⅳ型胶原(CⅣ)、层黏蛋白(LN)较对照组差异显著(P<0 05,P<0. 01)。结论:丹参注射液联合高压氧治疗对慢性肝病和肝纤维化指标有明显的改善作用。
Objective: To investigate the effect of Danshen injection combined with hyperbaric oxygen on chronic liver disease and liver fibrosis. Methods: In the control group, 21 cases of chronic liver disease were treated with conventional liver protection, Jiangmen, Huanghuang (Glycyrrhizin, reduced glutathione, potassium magnesium aspartate, Smectite and multivitamins) Note compound Danshen injection; hyperbaric oxygen group of 22 patients on the basis of the above treatment with hyperbaric oxygen therapy. Results: After 45 days and 90 days of treatment, the levels of serum hyaluronan (HA), collagen Ⅳ (Ⅳ) and laminin (LN) in hyperbaric oxygen group were significantly different from those in control group (P <0.05, P <0.01 ). Conclusion: Salvia miltiorrhiza injection combined with hyperbaric oxygen treatment can significantly improve the indexes of chronic liver disease and liver fibrosis.