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膜周部室间隔缺损(室缺)是最常见的先天性心脏病。自从本世纪初Amplatzer膜周型封堵器被广泛应用于膜周部室缺介入封堵治疗。同时新型改良设计的Amplatzer封堵器陆续问世,以及多种Amplazter封堵器非常规应用于膜周部室缺封堵,并开展了大量的临床应用研究。目前由于应用初代Amplatzer膜周型封堵器后近期或远期完全性房室传导阻滞并发症发生率较高,许多中心放弃了对其继续研究应用。对于完全性房室阻滞的机制深入探究以及封堵器选择应用进一步优化,将使Amplatzer封堵器在临床中具有广泛的应用空间,并为膜周部室缺的介入封堵治疗提供了新的思路。
Peripheral ventricular septal defect (ventricular septal defect) is the most common congenital heart disease. Since the beginning of this century, Amplatzer pericardial occluder has been widely used in the peri-ventricular septal defect. At the same time, a new modified Amplatzer occluder has been introduced one after another, and a variety of Amplazter occluder unconventional applications in the peri-membrane space plugging, and carried out a large number of clinical applications. At present, due to the high incidence of recent or long-term complete atrioventricular block after the application of the first generation Amplatzer perimembranous occluder, many centers have abandoned their research and application. In-depth exploration of the mechanism of complete atrioventricular block and the further optimization of occluder selection and application will make Amplatzer occluder have a wide range of clinical applications, and provide a new Ideas.