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关于氯丁二烯及其化合物对人的皮肤致癌可能性,在实践中是极为重要的问题,但迄今尚未研究。一些学者指出氯丁二烯对人的皮肤局部作用可以引起明显的病理改变——从皮炎、皲裂到覆硬痂的浅层溃疡坏死。在氯丁二烯环形二聚体的作用下,同样发生明显的秃头,伴有毛囊和皮脂腺的萎缩和消失、表皮增厚、角化和角化不良。组织化学和生化研究结果证明了在氯丁二烯作用下的脱发,系因在二硫化物中巯基氧化,影响角蛋白形成所致。然而接触氯丁二烯及其化合物(乳胶、橡胶、橡皮等)的人皮肤上的这些病理变化
The possibility that chloroprene and its compounds are carcinogenic to human skin is an extremely important issue in practice but so far it has not been studied. Some scholars have pointed out that the local effects of chloroprene on human skin can cause significant pathological changes - from dermatitis, chapped to superficial ulcer necrosis. In the presence of chloroprene ring dimers, significant baldness also occurs with atrophy and disappearance of hair follicles and sebaceous glands, thickening of the epidermis, keratosis and poor keratinization. Histochemistry and biochemical studies have shown that the hair loss in the role of chloroprene, the Department of disulfide in the Department of sulfhydryl oxidation, the impact of keratin formation. However, these pathological changes on human skin exposed to chloroprene and its compounds (latex, rubber, eraser, etc.)