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目的观察多西紫杉醇联合替吉奥治疗晚期胃癌的临床疗效及不良反应。方法将84例晚期胃癌患者随机分为实验组和对照组,每组42例。试验组接受多西紫杉醇75 mg/m2静脉滴注,第1天,替吉奥80 mg/m2,分2次,餐后口服,第1~14天,21 d为1个周期,至少化疗2个周期;对照组化疗方案为顺铂25 mg/m2,静脉滴注,第1~3天,醛氢叶酸钙200 mg/m2,静脉滴注,第1~5天,5-氟尿嘧啶500 mg/m2,第1~5天(在CF之后),28 d为1个周期,至少化疗2个周期。评价两组疗效及不良反应。结果试验组有效率为57.1%,中位疾病进展时间9.3个月,中位生存期14.3个月,1、2年生存率分别为57.1%和21.4%;对照组有效率为42.9%,中位疾病进展时间6.1个月,中位生存期10.2个月,1、2年生存率分别为38.1%和9.5%。两组疗效差异有统计学意义(P<0.05)。主要毒副反应为骨髓抑制和胃肠道反应,大部分患者可耐受。结论多西紫杉醇联合替吉奥治疗晚期胃癌的近期疗效好,且不良反应可以耐受,值得进一步研究。
Objective To observe the clinical efficacy and side effects of docetaxel combined with tegaserod in the treatment of advanced gastric cancer. Methods 84 patients with advanced gastric cancer were randomly divided into experimental group and control group, 42 cases in each group. The experimental group received intravenous infusion of docetaxel 75 mg / m2, on the first day, for Giovanostat 80 mg / m2, 2 times, after oral administration, the first to 14 days, 21 d for a cycle, at least chemotherapy 2 The control group chemotherapy was cisplatin 25 mg / m2, intravenous infusion, the first to third days, calcium dihydrofusiol 200 mg / m2, intravenous drip, the first 5 days, 5-fluorouracil 500 mg / m2, 1 to 5 days (after CF), 28 d for 1 cycle, at least 2 cycles of chemotherapy. Efficacy and adverse reactions were evaluated in both groups. Results The effective rate of the experimental group was 57.1%, the median time to progression was 9.3 months, the median survival time was 14.3 months, and the 1-year and 2-year survival rates were 57.1% and 21.4% respectively. The effective rate of the control group was 42.9% The disease progression was 6.1 months, with a median survival of 10.2 months. The 1-year and 2-year survival rates were 38.1% and 9.5%, respectively. The difference between the two groups was statistically significant (P <0.05). The main side effects of bone marrow suppression and gastrointestinal reactions, most patients can tolerate. Conclusion Docetaxel combined with tegaserod for the treatment of advanced gastric cancer has a good short-term curative effect and the side effects can be tolerated. Therefore, it is worth further study.