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19世纪,法国生理学家 Paul Verte 发现低氧可以刺激血红细胞生长。1950年美国 Reissman 证实了体内存在一种能刺激血红细胞的物质,称为红细胞生成素(EPO)。1985年,美国的 Fritsch 等成功地从成百上千的基因中发现了能产生 EPO 的一种,运用遗传工程,得以从动物细胞中产生对人类 EPO 负责的基因,从而使大量生产 rHuEPO 成为可能。EPO 是由肾脏分泌的一种重要激素,它具有促进骨髓中红细胞系列的增殖、分化、成熟和释放作用,以及维持血中细胞数和血红蛋白量的稳定状态慢性肾功能衰竭(CRF)的贫血与许多因素有关,这些因素包括:促红细胞生成素(EPO)生成减少、血中存在红细胞生成抑制因子(Inhibitors of Erythropoicsis,IE)、红细胞寿命缩
In the 19th century, French physiologist Paul Verte found that hypoxia stimulated the growth of red blood cells. 1950 Reissman confirmed that there is a substance that can stimulate red blood cells in the body called erythropoietin (EPO). In 1985, Fritsch et al. In the United States successfully discovered hundreds of EPO-producing genes and genetically engineered to produce genes responsible for human EPO from animal cells, making it possible to mass-produce rHuEPO . EPO is an important hormone secreted by the kidneys and has the effect of promoting the proliferation, differentiation, maturation and release of erythrocyte series in the bone marrow and the steady-state chronic renal failure (CRF) anemia that maintains the amount of blood cells and hemoglobin and A number of factors are involved, including the reduction of erythropoietin (EPO) production, the presence of Inhibitors of Erythropoietic Isis (IE), the reduction of erythrocyte lifespan