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RNA干扰(RNAi)是一种在动植物中广泛存在的、由双链RNA诱发的、同源mRNA特异性沉默的过程,包括小干扰RNA生成的起始阶段及靶mRNA降解的效应阶段。已成为分子生物学研究中最为活跃的热点之一;在肿瘤研究中,RNAi在抑制肿瘤抗凋亡基因、沉默癌基因、调控细胞周期、抗血管生成、增强放化疗敏感性及基因功能研究等有较广泛的应用。
RNA interference (RNAi) is a process that is widely existed in animals and plants and is induced by double-stranded RNA. The process of specific silencing of homologous mRNA includes the initial stage of small interfering RNA (RNAi) and the effector phase of target mRNA degradation. Has become one of the most active hotspots in molecular biology research. In tumor research, RNAi is one of the most important molecular mechanisms in the field of cancer research, including inhibiting tumor anti-apoptotic genes, silencing oncogenes, regulating cell cycle, anti-angiogenesis, enhancing chemoradiation and gene function Have a wider range of applications.