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作者采用气道吸入不同浓度DL-盐酸心得安测定12例哮喘患者的气道反应性,并与乙酰甲胆碱吸入激发试验进行了对比。结果表明:12例对乙酰甲胆碱激发呈阳性反应,其中11例对心得安也呈阳性反应,阳性率为91.7％,心得安PC_(20)与乙酰甲胆碱PC_(20)无关(r=0.3770,P>0.05),与基础FEV_1也无相关性(r=0.1765,P>0.05),但乙酰甲胆碱PC_(20)与基础FEV_1呈正相关(r=0.6223,P<0.05)。以上结果提示,心得安吸入激发试验可作为非特异性气道反应性测定方法,为哮喘的诊断提供客观依据。其激发机制与乙酰甲胆碱不同,因而在哮喘发病机理和治疗的研究中有不同的意义。
The authors used airway inhalation of different concentrations of DL-hydrochloric acid propranolol determination of 12 cases of asthmatic patients with airway responsiveness and methacholine inhalation challenge test were compared. The results showed that: 12 cases of methacholine positive reaction, of which 11 cases of propranolol was also positive, the positive rate was 91.7%, PC = (20) and methacholine PC_ (20) has nothing to do (r (R = 0.1765, P> 0.05). However, methacholine PC 20 had a positive correlation with basal FEV 1 (r = 0.6223, P <0.05). These results suggest that propranolol inhalation challenge test can be used as a non-specific airway reactivity assay to provide an objective basis for the diagnosis of asthma. Its mechanism of activation is different from that of methacholine and thus has different meanings in the study of the pathogenesis and treatment of asthma.