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目的:了解贵州省2009年甲型H1N1流感大流行高峰后期人群感染水平及流行趋势。方法:于2010年1月4日-2010年3月29日共4次在贵阳市随机抽取医院门诊患者、血液中心志愿者,利用血凝抑制(HI)方法进行血清标本甲型H1N1流感抗体检测。结果:4次调查的人群抗体阳性率依次为27.17%、14.99%、23.65%、12.59%。不同时间段之间抗体阳性率的差别有统计学意义(P<0.05)。男女性别之间抗体水平差别无统计学意义(P>0.05)。4个年龄组中6岁～17岁组抗体阳性率除第2次调查时略低于0岁～5岁组,其余3次均为最高。接种甲型H1N1流感疫苗的人群抗体阳性率为48%,高于非接种者的18.75%。结论:贵阳市人群甲型H1N1流感抗体水平较低,仍需加强防控,及时接种流感疫苗是获得保护性抗体最有效的途径。
OBJECTIVE: To understand the level of infection and epidemic trend of late 2009 peak population of Influenza A (H1N1) in Guizhou Province. Methods: From January 4, 2010 to March 29, 2010, a total of 4 outpatient clinics and blood center volunteers were randomly selected in Guiyang. Serum samples of influenza A (H1N1) antibody were detected by hemagglutination inhibition (HI) . Results: The positive rates of antibody in four surveys were 27.17%, 14.99%, 23.65% and 12.59%, respectively. The positive rate of antibody between different time periods was statistically significant (P <0.05). There was no significant difference in antibody levels between men and women (P> 0.05). The antibody positive rate of 6 years old to 17 years old group in 4 age groups except for the second survey was slightly lower than 0 years old to 5 years old group, the other three times were the highest. The antibody positive rate of the group vaccinated with influenza A (H1N1) was 48%, higher than that of non-vaccinated people (18.75%). Conclusion: The level of antibody against influenza A (H1N1) in Guiyang is still low, and the prevention and control of influenza A (H1N1) should be strengthened. It is the most effective way to obtain the protective antibody by timely vaccination.