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目的探讨血清ＴＧＦβ１和糖尿病肾病的关系。方法４５例２型糖尿病根据原白蛋白排泄率（ＵＡＥＲ）分为正常蛋白尿组（ＮＡ）、微量蛋白尿组（ＭＡ）、临床蛋白尿组（ＯＤＮ）。分别检测各组的血清ＴＧＦβ１、空腹血糖（ＦＢＧ）、糖化血红蛋白（ＨｂＡｌｃ）及肾功能（ＢＵＮ、Ｃｒ、Ｃｃｒ）。ＭＡ、ＯＤＮ分别分为卡托普利治疗组、常规治疗组。结果糖尿病三组与正常对照组比较血清ＴＧＦβ１有显著性差异，ＯＤＮ与ＭＡ、ＮＡ比较也有显著性差异。相关分析表明血清ＴＧＦβ１与血Ｃｒ、ＨｂＡｌｃ、ＵＡＥＲ呈正相关。ＭＡ和ＯＤＮ两组中卡托普利治疗前后ＴＧＦ民有显著性差异。结论糖尿病肾病患者血清ＴＧＦ昆明显增高，且和糖化血红蛋白、肾功能损害呈明显正相关。血管紧张素转换酶抑制剂能部分地纠正 ＤＮ ｔ者的血清ＴＧＦβ１变化。
Objective To investigate the relationship between serum TGFβ1 and diabetic nephropathy. Methods Forty-five type 2 diabetic patients were divided into normal proteinuria group (NA), microalbuminuria group (MA) and clinical proteinuria group (ODN) according to the albumin excretion rate (UAER). The serum TGFβ1, fasting blood glucose (FBG), HbA1c and renal function (BUN, Cr, Ccr) were detected in each group. MA, ODN were divided into captopril treatment group, conventional treatment group. Results There were significant differences in serum TGFβ1 between the three diabetic groups and the normal control group. There was also a significant difference between ODN and MA and NA. Correlation analysis showed that serum TGFβ1 was positively correlated with serum Cr, HbAlc and UAER. There was a significant difference between the two groups before and after treatment with captopril in both MA and ODN groups. Conclusions Serum TGF-kun in diabetic nephropathy patients is obviously higher than that in patients with diabetic nephropathy, which is positively correlated with glycosylated hemoglobin and renal dysfunction. Angiotensin converting enzyme inhibitors can partially correct the change of serum TGFβ1 in DN t.