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目的 :观察强化生活方式干预对长沙市糖调节受损人群的效果。方法 :对长沙市2610名社区居民健康普查中筛选出的100例IGR患者,随机分为强化生活方式干预组和对照组,接受6个月的强化生活方式干预,在研究开始和结束对所有研究对象进行体格检查(包括身高、体重、腰围、臀围、血压)和生化指标(包括FPG、OGTT2hPG、血脂四项(TC、TG、H-LDL,L-LDL)、尿酸)。结果 :与对照组比较,干预组患者BMI值、腰/臀比、血压、FPG、OGTT2hPG、TC、TG、L-LDL、尿酸水平明显下降。HDL-C水平升高不明显。对照组的糖尿病6个月累积发病率为10%,而干预组未发现糖尿病。对照组6个月累积血糖转变为正常率为4%,低于干预组(18%)。结论 :强化生活方式干预可以改善长沙市居民的代谢相关指标,降低糖尿病发病风险,促进向正常血糖转化。
Objective: To observe the effects of intensive lifestyle intervention on impaired glucose regulation in Changsha. Methods: A total of 100 IGR patients screened from 2610 community health censuses in Changsha were randomly divided into intensive lifestyle intervention group and control group, and received intensive lifestyle intervention for 6 months. All studies were completed at the beginning and end of the study Subjects underwent physical examination (including height, weight, waist circumference, hip circumference, blood pressure) and biochemical indicators (including FPG, OGTT2hPG, four lipids (TC, TG, H-LDL, L-LDL) and uric acid. Results: Compared with the control group, BMI, waist / hip ratio, blood pressure, FPG, OGTT2hPG, TC, TG, L-LDL and uric acid in the intervention group decreased significantly. HDL-C level is not obvious. The cumulative incidence of diabetes 6 months in the control group was 10%, while the intervention group did not find diabetes. The 6 months cumulative blood glucose in the control group changed to a normal rate of 4%, lower than the intervention group (18%). Conclusion: Intensive life style intervention can improve the metabolism related indicators of Changsha residents, reduce the risk of diabetes and promote the conversion to normal blood glucose.