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目的评价急性心肌梗死患者急诊介入前持续静脉泵注替罗非班对介入治疗的影响。方法介入前79例急性心肌梗死患者,随机分为对照组(38例)、替罗非班组(41例)。两组均给予常规治疗,替罗非班组在常规治疗基础上加用替罗非班持续静脉泵注。观察两组急诊冠脉介入治疗(PCI)手术中冠脉造影前向血流充盈、冠脉血栓形成情况;术后72 h 心电图 ST 改变及缺血导联累及数;术后72 h 内室速及室颤发生总次数及术后主要终点事件。结果与对照组比较,术中替罗非班组前向血流 TIMI 分级明显提高(P<0.05),冠脉内血栓形成减轻(P<0.05);术后心电图 ST 段缺血改善,缺血导联数下降,室速及室颤发生减少(均 P<0.05);但术后主要终点事件发生率无差别(P>0.05)。结论对急性心肌梗死患者,急诊冠脉介入前使用替罗非班可获得较好效果。
Objective To evaluate the effect of continuous intravenous infusion of tirofiban on the interventional therapy in patients with acute myocardial infarction before emergency intervention. Methods 79 patients with acute myocardial infarction before intervention were randomly divided into control group (38 cases) and tirofiban group (41 cases). Both groups were given conventional treatment, tirofiban group in the conventional treatment based on the addition of tirofiban continuous intravenous infusion. The blood flow and coronary thrombosis before coronary angiography in two groups of patients undergoing PCI were observed. ST changes and the number of ischemic leads involved at 72 hours after operation were recorded. The ventricular tachycardia And the total number of ventricular fibrillation and postoperative main end point events. Results Compared with the control group, the TIMI grade was significantly increased (P <0.05) and the coronary thrombosis was relieved (P <0.05). The postoperative ischemic insult The number of decreased, ventricular tachycardia and ventricular fibrillation decreased (all P <0.05), but there was no significant difference in the incidence of postoperative major endpoint events (P> 0.05). Conclusions For patients with acute myocardial infarction, the use of tirofiban before emergency coronary intervention may achieve better results.