论文部分内容阅读
目的探讨IgG4相关性疾病的临床表现、病理学特征及影像学表现。方法分析4例IgG4相关性疾病的临床特征、组织病理学及影像学改变,并查阅相关文献进行总结。结果本组4例的平均年龄为55岁,男女比例为3∶1。分别发生于颌下腺2例、眼眶1例、颜面部1例。临床表现无显著特异性,均呈无痛渐进性肿胀。病理学改变为淋巴组织及纤维组织增生,其内有较多浆细胞浸润(IgG4阳性浆细胞>50个/HPF,IgG4阳性浆细胞>IgG阳性浆细胞的40%)。影像学上表现为病变区炎性改变。结论IgG4相关性疾病是目前临床较为少见的疾病,发病机制尚不明确。需结合临床表现、血清学检测、病理学特征及影像学表现做出最终诊断,进而行及时准确的治疗。
Objective To investigate the clinical manifestations, pathological features and imaging findings of IgG4-related diseases. Methods The clinical features, histopathology and imaging changes of 4 cases of IgG4 related diseases were analyzed. The related literatures were reviewed and summarized. Results The average age of 4 cases in this group was 55 years old, the ratio of male to female was 3: 1. Occurred in the submandibular gland in 2 cases, 1 case of orbital, facial 1 case. No significant clinical manifestations, showed painless gradual swelling. Pathological changes of lymphoid tissue and fibrous tissue hyperplasia, there are more plasma cells infiltration (IgG4-positive plasma cells> 50 / HPF, IgG4-positive plasma cells> 40% of IgG-positive plasma cells). Imaging showed inflammatory changes in the lesion area. Conclusion IgG4-related diseases are the less common clinical diseases at present. The pathogenesis of IgG4 is not yet clear. Need to combine clinical manifestations, serological tests, pathological features and imaging findings to make the final diagnosis, and then line timely and accurate treatment.