Simulation of tumor microvasculature and microenvironment response to anti-angiogenic treatment by a

• 作 者: Jie WU Zu-rong DING Yan CAI Sh
• 机 构: School of Naval Architecture,Department of Mechanics and Engineering Science,School of Medical Instr
• 出 处: 应用数学和力学（英文版）
• 发表日期: 2004年期
• 关键词: solid tumor microenvironment normalization numerical simulation anti-angiogenesi

The effects of anti-angiogenesis treatment by angiostatin and endostatin on normalization of tumor microvasculature and microenvironment are investigated, based on mathematical modeling and numerical simulation of tumor anti-angiogenesis and tumor haemodynamics. The results show that after anti-angiogenesis treatment: (i) the proliferation, growth, and branching of neo-vessels are effectively inhibited, and the extent of vascularization in tumors is accordingly reduced. (ii) the overall blood perfusion inside of tumor is declined, the plateau of tumor interstitial fluid pressure (IFP) is relieved, the interstitial fluid oozing out from the tumor periphery into the surrounding normal tissue is reduced, the reduction of overall extravasation across vasculature to tumor interstium is much less than the decreased overall blood perfusion, due to the decline of IFP, the intravasations is remarkablely effected by the change, in some cases there are no intravasation flow appear.