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目的 :研究温肾方对自身免疫性甲状腺炎 SD大鼠抗体滴度及病理改变的影响。方法 :用 RIA方法观察 SD大鼠发生自身免疫性甲状腺炎时抗体滴度水平的改变及病理改变 ,了解温肾方等对自身免疫性甲状腺炎发生的干预作用。结果 :实验性自身免疫性甲状腺炎大鼠的 TGAb、TPOAb水平均明显高于温肾方组、雷公藤组 ,各实验组与对照组比较差异均有显著性 (P<0 .0 5或 P<0 .0 1)。温肾方组、雷公藤组甲状腺炎病变程度较建模组轻。结论 :温肾方、雷公藤对自身免疫性甲状腺炎能起到有效的预防及治疗作用
Objective : To study the effect of Wenshen Prescription on the antibody titer and pathological changes of SD rats with autoimmune thyroiditis. Methods: The RIA method was used to observe the changes of antibody titer and pathological changes in autoimmune thyroiditis in SD rats, and to understand the intervention of Wen Shen Fang et al. on the occurrence of autoimmune thyroiditis. RESULTS: The levels of TGAb and TPOAb in experimental autoimmune thyroiditis rats were significantly higher than those in Wenshen prescription and Tripterygium wilfordii group. The differences between experimental groups and control groups were significant (P<0.05 or P). <0. 0 1). The severity of thyroiditis in the Wenshenfang and Tripterygium wilfordii group was lighter than that in the modeling group. Conclusion: Wenshen Fang and Tripterygium wilfordii can effectively prevent and treat autoimmune thyroiditis.