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近年米,由于医生或病人自己滥用药物而引起的医源性疾病逐渐增多,从而引起了人们的重视。药物对脏器的损害是广泛的,而药物性肝损害是其重要方面之一。据国外统计,致肝损害的常用药物中,抗生素约占50%,磺胺类药物、退热药等约占25%,其它药物为25%。在小儿,引起肝损害的常用药物是抗生素、肾上腺皮质激素、抗肿瘤药物、免疫抑制剂、退热药和抗惊厥药物等。一、药物性肝损害的发病机理:目前认为药物可能通过两种机理引起肝损害: (一)中毒性肝损害:由药物直接引起的中
In recent years, the increasing number of iatrogenic diseases caused by doctors and patients’ own abuse of drugs has attracted people’s attention. Drug damage to organs is widespread, and drug-induced liver damage is one of its important aspects. According to foreign statistics, antibiotics account for about 50% of commonly used drugs that cause liver damage, about 25% for sulfa drugs, antipyretics, and 25% for other drugs. In children, commonly used drugs that cause liver damage are antibiotics, adrenal hormones, antineoplastic drugs, immunosuppressive agents, antipyretics and anticonvulsants. First, the pathogenesis of drug-induced liver damage: It is currently believed that the drug may cause liver damage through two mechanisms: (a) toxic liver damage: caused directly by the drug