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目的:探讨TopoⅡ、P-cadherin、Caveolin-1及Bmi-1蛋白在乳腺癌组织中的表达及意义。方法:回顾性分析经证实的312例女性乳腺癌病理资料,应用免疫组化检测乳腺癌组织中的TopoⅡ、P-cadherin、Caveolin-1及Bmi-1蛋白的表达。结果:在312例乳腺癌中,TopoⅡ、P-cadherin、Caveolin-1及Bmi-1蛋白的阳性表达率分别为87.18%(272/312)、41.67%(130/312)、57.05%(178/312)、75.64%(236/312)。TopoⅡ表达与组织学分级、淋巴结是否转移、临床TNM分期有显著关系(P<0.05);P-cadherin表达与乳腺癌的组织学分级、淋巴结是否转移、临床TNM分期、ER、PR及HER2均有关系(P<0.05);Caveolin-1表达与淋巴结是否转移、临床TNM分期以及HER2表达有显著的相关性(P<0.05);Bmi-1蛋白表达与临床TNM分期升高和淋巴结是否转移具有显著的统计学意义(P<0.05)。结论:TopoⅡ、P-cadherin、Caveolin-1及Bmi-1蛋白的检测对乳腺癌的预后以及选择化疗方案有重要的指导意义。
Objective: To investigate the expression and significance of TopoⅡ, P-cadherin, Caveolin-1 and Bmi-1 in breast cancer. Methods: A retrospective analysis of 312 cases of breast cancer confirmed pathological data, the application of immunohistochemical detection of breast cancer Topo Ⅱ, P-cadherin, Caveolin-1 and Bmi-1 protein expression. Results: The positive expression rates of TopoⅡ, P-cadherin, Caveolin-1 and Bmi-1 protein in 312 cases of breast cancer were 87.18% (272/312), 41.67% (130/312) and 57.05% (178 / 312), 75.64% (236/312). There was a significant relationship between TopoⅡexpression and histological grade, lymph node metastasis and TNM staging (P <0.05). P-cadherin expression correlated with histological grade, lymph node metastasis, TNM staging, ER, PR and HER2 (P <0.05). There was a significant correlation between the expression of Caveolin-1 and lymph node metastasis, clinical TNM stage and HER2 expression (P <0.05). The expression of Bmi-1 protein was significantly correlated with the clinical TNM stage and lymph node metastasis The statistical significance (P <0.05). Conclusion: The detection of TopoⅡ, P-cadherin, Caveolin-1 and Bmi-1 protein has an important guiding significance for the prognosis of breast cancer and the choice of chemotherapy regimen.