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目的探讨重症手足口病患儿脑脊液白细胞计数和生化检查以及血清心肌酶谱相互之间的关系。方法回顾性分析59例重症患儿入院后1～3d脑脊液白细胞计数和生化及心肌酶谱检查的临床资料。结果重症患儿脑脊液白细胞计数升高占96.6%,以单核细胞升高为主(89.4%),个别细胞数明显升高,基本符合病毒性脑炎的特点。和手足口病普通病例相比,蛋白定量、心肌酶谱的LDH、α-HBDH差异有统计学意义。结论对有重症倾向的手足口病患儿进行脑脊液和常规心肌酶谱检查,有利于重症的早期诊断。
Objective To investigate the relationship between cerebrospinal fluid white blood cell count, biochemical tests and serum myocardial enzymes in children with severe hand-foot-mouth disease. Methods The clinical data of cerebrospinal fluid white blood cell count, biochemical and myocardial enzymes in 59 severe children admitted to hospital from January to April were retrospectively analyzed. Results The percentage of cerebrospinal fluid leucocyte increased 96.6% in severe children (89.4%), and the number of individual cells increased significantly, which basically accorded with the characteristics of viral encephalitis. Compared with the common cases of hand, foot and mouth disease, the differences of LDH and α-HBDH in protein and myocardial enzymes were statistically significant. Conclusion Cerebrospinal fluid (CSF) and routine myocardial enzyme examination in HFMD children with severe tendency are helpful for the early diagnosis of severe diseases.